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| Stem Cells Regenerative Medicine Unit |
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Adult Stem Cell Therapy. The goal of overcoming the physical decline associated with aging is as old as mankind itself. Science has played a critical role in the development of treatments and products designed to expand and enhance quality of life over the years.
Perhaps the most amazing and promising of all breakthroughs has been Cell Therapy, performed with the use of adult stem cells derived from various sources such as adipose tissue, fetal chord, amniotic fluid and bone marrow.
At Regenalpha, the patient’s own bone marrow stem cells are collected in an outpatient procedure. The stem cells are then processed in the laboratory where they are expanded and multiplied millions of times. They are then frozen in vials at low temperatures in order to have available stock for regenerative therapies and for the treatment of various diseases. At present there is a large number of studies and ongoing clinical trials showing the effectiveness of these cells in the treatment and cure of endocrine, neurological, cardiovascular, muscle, hepatic, renal and rheumatologic diseases, thus improving the quality of life of the people diagnosed with those diseases.
The cells can be administered intravenously or intra-arterially, depending on the treatment goal.
For regenerative therapy, cells are applied once a year in the form of an “anti-aging vaccine”.
Regenerative Medicine – Stem Cells
CECOLFES developed the First Latin-American Embryionic Stem Cell Line - Cecol-14 – that showed, by immune characterization, a marker profile that confirms their pluripotency, with a 46, XX karyotype and normal FISH. The Cecol-14 cell line opens a new possibility for studying the development of stem cell replacement therapies for eventual clinical application once human-derived cell lines are developed.
Great progress has been made in the past 15 years in the area of stem cell research with both adult and embryonic stem cells.
It is undeniable that these cells may be the solution the scientific community has been waiting for to alleviate symptoms and even cure countless diseases classified as incurable until recently.
There are two types of stem cells:
Embryonic and Adult Stem Cells
Embryonic Stem Cells Embryonic stem cells are derived from the inner cell mass of 6-day embryos.
These cells are undifferentiated or non-specialized, and they have the potential to generate all the cells in the human body. They are capable of proliferating indefinitely in culture, thus becoming an unlimited source of specialized cells once they are induced to differentiate into bone, muscle, liver, blood, heart, neuronal or other types of cells. No clinical trials have been undertaken to date with this type of cells because there are still problems to be solved before they can be used safely in humans. Scientists have also demonstrated that these cells have the biggest potential for use in patients because they are “young cells” with a high self-renewal and differentiation capability.
Adult Stem Cells
These are undifferentiated cells found in most organs and tissues.
Anti-aging vaccines: CECOLFES has implemented a procedure, similar to chelation, consisting of the intravenous infusion of millions of the patients’ own stem cells. Given the ability of these cells to migrate to damaged sites and promote tissue regeneration, this strategy can be an excellent way to provide anti-aging treatment. There is a revolution afoot in the field of human health, and we are part of it at CECOLFES. We continue to do research and work in our laboratories to offer patient safe state-of-the-art regenerative medicine.
It was the belief until recently that Adult Stem Cells could only differentiate to cells of their own organ of origin, but there are countless current studies showing that they can actually differentiate to other types of cells. However, the mechanisms for how this happens are not yet well understood.
Stem cells are also found in adipose tissue, amniotic fluid, umbilical chord blood and bone marrow.
The potential applications of these cells include treatment of injuries and diseases such as Parkinson’s, Alzheimer’s, diabetes, and heart diseases among others. A large number of animal studies have shown encouraging results and there are several ongoing clinical trials for Type 2 Diabetes, heart conditions, and degenerative diseases.
Stem cells in anti-aging medicine
The most important applications in this area include the generation of specialized cells and tissues to treat several clinical disorders.
1. Chronic Heart Diseases: It is already possible to generate heart cells in the laboratory. Stem cells can be used in the patient to generate new heart tissue. There are ongoing clinical trials using bone marrow-derived stem cells for direct infusion into the heart.
2. Diabetes: In Type 1 diabetes, daily injections of insulin are required because of the person’s inability to produce this hormone. Stem cell derived insulin-producing cells can now be produced in the laboratory, and they could be used in these patients to help the pancreas produce its own insulin. In this way, there would no longer be a need for daily injections.
3. Parkinson’s Disease: Patients with this disease suffer from tremors and loss of muscle control resulting from a progressive loss of dopamine-producing brain cells. These cells could be replaced by stem cells differentiated to that cell type.
4. Spinal chord injuries: It is possible now to generate cells that are capable of repairing spinal chord damage. Studies in mice have shown the possibility of recovering lower limb mobility after injection of cells directly on the site of injury. It is also possible to treat several autoimmune disorders such as lupus, scleroderma, rheumatoid arthritis and multiple sclerosis by transplanting blood stem cells.
Other diseases that could be treated with the use of stem cells include:
Metabolic:
• Osteogenesis imperfecta
• Hurler’s Syndrome
• Adrenoleukodistrophy
Ocular:
• Corneal regeneration
Liver: • Chronic liver disease – cirrhosis |
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